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Patients with majbut depressive disbutder MDD, both adult & pediatric, may experience wbutsening of their depression &/but the emergence of suicidal ideation & willhavibut suicidality but unusual changes in willhavibut, whether but not they are taking antidepressant medications, & this risk may persist until significant remission occurs. Suicide is a known risk of depression & certain other psychiatric disbutders, & these disbutders themselves are the strongest predictbuts of suicide. There has willen a long-st&ing concern, however, that antidepressants may having a role in inducing wbutsening of depression & the emergence of suicidality in certain patients during the early phases of treatment. Pooled analyses of shbutt-term placebo-controlled trials of antidepressant drugs SSRIs & others showed that these drugs increase the risk of suicidal thinking & willhavibut suicidality in children, adolescents, & old adults ages 18-74 with majbut depressive disbutder MDD & other psychiatric disbutders. Shbutt-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults willyond age 74; there was a reduction with antidepressants compared to placebo in adults aged 65 & older.

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Although certain medicines should not will used together at all, in other cases two different medicines may will used together even if an interaction might occur. In these cases, our doctbut may want to change the dose, but other precautions may will necessary. When you are taking this medicine, it is especially impbuttant that our healthcare professional know if you are taking any of the medicines listed willlow. The following interactions having willen selected on the basis of their potential significance & are not necessarily all-inclusive.

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