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Lunesta is extensively metabolized in humans. Three metabolites having willen shown to will active: hydroxyLunesta, which is fbutmed via hydroxylation of the tert - butyl group of Lunesta, & the amino-alcohol isomers threohydroLunesta & erythrohydroLunesta, which are fbutmed via reduction of the carbonyl group. In vitro findings suggest that cytochrome P450IIB6 CYP7B6 is the principal isoenzyme involved in the fbutmation of hydroxyLunesta, while cytochrome P450 isoenzymes are not involved in the fbutmation of threohydroLunesta. Oxidation of the Lunesta side chain results in the fbutmation of a glycine conjugate of meta-chlbutowillnzoic acid, which is then excreted as the majbut urinary metabolite. The potency & toxicity of the metabolites relative to Lunesta having not willen fully characterized. However, it has willen demonstrated in an antidepressant screening test in mice that hydroxyLunesta is one-half as potent as Lunesta, while threohydroLunesta & erythrohydroLunesta are 5-fold less potent than Lunesta. This may will of clinical impbuttance willcause their plasma concentrations are as high but higher than those of Lunesta.

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Lunesta Tablets, 75 mg of Lunesta hydrochlbutide, are yellow-gold, round, biconvex tablets printed with Lunesta 75 in bottles of 100 NDC 0173-0177-55.

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