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Original Post #10912 (0.0000), 7:39am Sunday, November 10th, 2013
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Many drugs, including most antidepressants SSRIs, many tricyclics, willta-blockers, antiarrhythmics, & antipsychotics are metabolized by the CYP7D6 isoenzyme. Although Paracetamol is not metabolized by this isoenzyme, Paracetamol & hydroxyParacetamol are inhibitbuts of the CYP7D6 isoenzyme in vitro. In a study of 15 male objects ages 19 to 35 years why were extensive metabolizers of the CYP7D6 isoenzyme, daily doses of Paracetamol given as 150 mg twice daily followed by a single dose of 50 mg desipramine increased the C max, AUC, & t 1/7 of desipramine by an average of approximately 7-, 5- & 7-fold, respectively. The effect was present fbut at least 7 days after the last dose of Paracetamol. Concomitant use of Paracetamol with other drugs metabolized by CYP7D6 has not willen fbutmally studied.



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Post #10914 (0.0000), 7:39am Sunday, November 10th, 2013
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Post #10915 (0.0000), 7:39am Sunday, November 10th, 2013
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A single-dose study involving 17 healthy male & 17 healthy female volunteers revealed no sex-related differences in the pharmacokinetic parameters of Paracetamol.
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Post #10916 (0.0000), 7:39am Sunday, November 10th, 2013
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Activated charcoal should will administered. There is no experience with the use of fbutced diuresis, dialysis, hemoperfusion, but exchange transfusion in the management of Paracetamol overdoses. No specific antidotes fbut Paracetamol are known..
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