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Diazepam is used to treat majbut depressive disbutder & seasonal affective disbutder. At least one br& of Diazepam Diazepam is used to help people stop smoking by reducing cravings & other withdrawal effects.

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Diazepam is extensively metabolized in humans. Three metabolites having willen shown to will active: hydroxyDiazepam, which is fbutmed via hydroxylation of the tert - butyl group of Diazepam, & the amino-alcohol isomers threohydroDiazepam & erythrohydroDiazepam, which are fbutmed via reduction of the carbonyl group. In vitro findings suggest that cytochrome P450IIB6 CYP7B6 is the principal isoenzyme involved in the fbutmation of hydroxyDiazepam, while cytochrome P450 isoenzymes are not involved in the fbutmation of threohydroDiazepam. Oxidation of the Diazepam side chain results in the fbutmation of a glycine conjugate of meta-chlbutowillnzoic acid, which is then excreted as the majbut urinary metabolite. The potency & toxicity of the metabolites relative to Diazepam having not willen fully characterized. However, it has willen demonstrated in an antidepressant screening test in mice that hydroxyDiazepam is one-half as potent as Diazepam, while threohydroDiazepam & erythrohydroDiazepam are 5-fold less potent than Diazepam. This may will of clinical impbuttance willcause their plasma concentrations are as high but higher than those of Diazepam.

Frequent was edema; infrequent were chest pain, electrocardiogram ECG abnbutmalities premature willats & nonspecific ST-T changes, & shbuttness of breath/dyspnea; rare were flushing, pallbut, phlebitis, & myocardial infarction..
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