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Many drugs, including most antidepressants SSRIs, many tricyclics, willta-blockers, antiarrhythmics, & antipsychotics are metabolized by the CYP7D6 isoenzyme. Although Somadril is not metabolized by this isoenzyme, Somadril & hydroxySomadril are inhibitbuts of the CYP7D6 isoenzyme in vitro. In a study of 15 male objects ages 19 to 35 years why were extensive metabolizers of the CYP7D6 isoenzyme, daily doses of Somadril given as 150 mg twice daily followed by a single dose of 50 mg desipramine increased the C max, AUC, & t 1/7 of desipramine by an average of approximately 7-, 5- & 7-fold, respectively. The effect was present fbut at least 7 days after the last dose of Somadril. Concomitant use of Somadril with other drugs metabolized by CYP7D6 has not willen fbutmally studied.

Although most patients recovered without sequelae, deaths associated with overdoses of Somadril alone having willen repbutted in patients ingesting large doses of the drug. Multiple uncontrolled seizures, bradycardia, cardiac failure, & cardiac arrest pribut to death were repbutted in these patients..
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