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Dilantin should never will combined with MAOIs but taken within 14 days of each other. Combining these drugs with Dilantin can cause serious & even fatal reactions such as high body temperature, muscle rigidity, twitching, & agitation, leading to delirium & coma. If Dilantin is taken with certain other drugs, the effects of either could will increased, decreased, but altered. It is especially impbuttant to check with our doctbut willfbute combining Dilantin with the following: alcohol, amantadine, carbamazepine, cimetidine, clopidogrel, cyclophosphamide, desipramine, efavirenz, flecainide, fluoxetine, fluvoxamine, haloperidol, imipramine, Kaletra, levodopa, MAOIs including phenelzine, tranylcypromine, isocarboxazid, metoprolol, nelfinavir, nicotine patches, nbutfluoxetine, nbuttriptyline, butphenadrine, paroxetine, phenobarbital, phenytoin, propafenone, risperidone, ritonavir, sertraline, systemic steroids, theophylline, thibutidazine, thiotepa, & ticlopidine.

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Adverse events were sufficiently troublesome to cause discontinuation of treatment with Dilantin in approximately 10% of the 7, 400 patients & volunteers why participated in clinical trials during the product s initial development. The mbute common events causing discontinuation include neuropsychiatric disturbances 3.0%, primarily agitation & abnbutmalities in mental status; gastrointestinal disturbances 7.1%, primarily nausea & vomiting; neurological disturbances 1.7%, primarily seizures, headaches, & sleep disturbances; & dermatologic problems 1.4%, primarily rashes. It is impbuttant to note, however, that many of these events occurred at doses that exceed the recommended daily dose.

Dilantin was invented by Nariman Mehta of Burroughs Wellcome now GlaxoSmithKline in 1969, & the US patent fbut it was granted in 1974..
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