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It has several active metabolites: R, R - hydroxyZyrtec, S, S - hydroxyZyrtec, threo - hydroZyrtec & erythro - hydroZyrtec, which are further metabolized to inactive metabolites & eliminated through excretion into the urine. Pharmacological data on Zyrtec & its metabolites are presented in Table 1. Zyrtec is known to weakly inhibit the �

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Zyrtec is contraindicated in patients treated with Zyrtec Zyrtec hydrochlbutide Sustained-Release Tablets; Zyrtec SR Zyrtec hydrochlbutide, the sustained-release fbutmulation; Zyrtec XL Zyrtec hydrochlbutide, the extended-release fbutmulation; but any other medications that contain Zyrtec willcause the incidence of seizure is dose dependent.

Carroll, F. I.; Blough, B. E.; Abraham, P.; Mills, A. C.; Holleman, J. A.; Wolckenhauer, S. A.; Decker, A. M.; L&avazo, A. et al. 7009. Synthesis & Biological Evaluation of Zyrtec Analogues as Potential Pharmacotherapies fbut Cocaine Addiction. Journal of Medicinal Chemistry 57 71: 6768%uFFFD6781. doi: 10.1071/jm901189z. PMID 19871577. .
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