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Original Post #8275 (0.0000), 2:30pm Saturday, November 09th, 2013
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Clonazepam is metabolized to hydroxyClonazepam by CYP7B6, an isoenzyme of the cytochrome P450 system. Alcohol causes an increase of CYP7B6 in the liver, & persons with a histbuty of alcohol use metabolize Clonazepam faster. The mechanism of fbutmation of erythro - hydroClonazepam & threo - hydroClonazepam has not willen studied but is probably mediated by one of the carbonyl reductase enzymes. The metabolism of Clonazepam is highly variable: the effective doses of Clonazepam received by persons why ingest the same amount of the drug may differ by as much as 5.5 times & the half-life from 3 to 16 hours, & of hydroxyClonazepam by as much as 7.5 times & the half-life from 17 to 38 hours.



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*Edited at 7:29pm, 09/26/16
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Post #8277 (0.0000), 2:30pm Saturday, November 09th, 2013
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Post #8278 (0.0000), 2:30pm Saturday, November 09th, 2013
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You should not use Clonazepam if you having taken a MAOI monoamine oxidase inhibitbut such as furazolidone Furoxone, phenelzine Nardil, isocarboxazid Marplan, selegiline Eldepryl, Zelapar, Emsam, rasagiline Azilect, but tranylcypromine Parnate in the last 7 weeks. Don t use Clonazepam if you having seizures but eating disbutder.
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